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Beauty is gut deep

by previlli

You have heard the saying that “beauty is only skin deep,” but new research on gut health is demonstrating that “beauty is actually gut deep.” It turns out that while we spend more than 5 billion dollars per year topically applying lotions and potions to the surface of our skin, our best beauty results are likely achieved from within. If you are interested in glowing, youthful, and healthy skin, gut health should be a top priority. The gut-skin relationship appears to be impaired in a number of skin conditions.

More than 80 years ago, John H. Stokes and Donald M. Pillsbury formulated the idea of the gut-brain-skin axis, but it is only recently that there has been an exponential boom in research related to how these three influence each other. This tri-directional superhighway is centered on the association between changes in emotional states (e.g., depression and anxiety), intestinal microbiota shifts, corresponding increases in intestinal permeability, elevated systemic inflammation, and attenuated or aggravated skin pathologies. Conversely, poor gut architecture and dysbiosis in the gut can go the other direction causing swings in mood and mental wellbeing, which then can play out on our skin. 

It is not our imagination that stress, lack of sleep, and tummy churning GI issues can also have a negative impact on our skin. Clinical studies show that digestive disorders often occur in conjunction to chronic skin conditions.

Your skin and your gut have more in common than you think.

The habitats of the skin and gut offer a beautiful and intricate portrait of the interaction between multiple, distinct, biological, and ecological systems. Scientists are only now learning to appreciate how these extraordinary environments collaborate and how their equally unique residents come together to form a dynamic ecosystem with a dizzying array of potential health implications. Though seemingly distinct, your skin and gut have a great deal in common. They are both marvels of nature and engineering wonders. For instance, the structures of the small intestine lining are designed to increase the surface area of your gut by over 100 times to magnify its ability to sense environmental changes and optimize nutrient absorption.

New research is showing how the gut microbiome may also influence the biome of the skin. Likewise, sun exposure, smoking, stress, pollution, poor diet, and aging all manifest themselves on the surface of the skin and cause fluctuations in the gut microbiota. 

The communication between your skin and gut is a function of two important things:

1)     Integrity and health of gut architecture, including mucosal immune system, barrier function, surface area, and lumen environment. Having a proper home or infrastructure for your microbiome is critical to facilitating communication, managing inflammation, and supporting immunity inside and outside of the gut. The gut’s mucosal barrier is a smart sensor designed to identify and sort which compounds should be transitioned to other parts of the body, like nutrients, hormones, and immune molecules, and which elements need to stay contained within its walls, including microorganisms, inflammatory molecules, and toxins. Ultimately, the gut barrier (colonocytes) are the control switch modulating microbial homeostasis from gut dysbiosis.

2)     Diversity and balance of the microbiome. When good bacteria eat, they ferment certain foods to create or stimulate by-product messenger molecules, including hormones, immune modulators, and short chain fatty acids (SCFA).  The number-one-way to influence the composition and metabolism of your gut bacteria is through what you feed them – that means diet and prebiotics.

Fermentation of prebiotics by the gut microbiota produces SCFAs, which improve the function and integrity of the gut, modulate the immune system and inflammatory response, and affect lipid and glucose metabolismIt is through immune system modulation that your gut exerts a powerful influence over your skin health. When the gut barrier is permeable instead of “water-tight,” things that should stay in the gut escape their proper habitat and cause trouble all over the body, including the skin.

You can have tons of good gut bacteria, but if you don’t provide them a good home and proper nutrition to do their job, then they get out of balance and can’t produce the molecule messengers that travel out of the gut and provide essential information, nutrition, and protection to our skin, brain, lungs, joints, and heart.

Many skin conditions are influenced by gut architecture and microbiome composition, everything from the markers of glowing and youthful skin to more aggressive and chronic skin conditions. 

Ways you might notice wellness in your gut is manifest on your skin:

a.      Protect the skin from UV damage

b.      Reduce the appearance of fine lines and wrinkles

c.      Improve elasticity and firmness

d.      Help your skin retain moisture and improve hydration

e.      Prevent or mediate some allergic skin conditions

f.       Calm and soothe blemished or troubled skin

g.      Support hormonal balance related to skin health

Recent studies have shown that improving gut health may reduce sun damage, increase skin elasticity and hydration, and even minimize wrinkles.  There is a growing body of research that microbes at one site can affect the host at other sites.  Researchers are finding the gut microbiome’s influence permeates the brain, respiratory and urogenital tracts, heart, and skin. These are exciting discoveries that could lead to new approaches to health maintenance, disease prevention, and even optimal aging. 

If you are looking to upgrade your skin routine, it might be time to do a little internal housekeeping – starting with good gut health!


Benhadou F, Mintoff D, Schnebert B, Thio HB. Psoriasis and Microbiota: A Systematic Review. Diseases. 2018;6(2):47. Published 2018 Jun 2. https://pubmed.ncbi.nlm.nih.gov/29865237/

Biagi, Elena et al. “Aging of the human metaorganism: the microbial counterpart.” Age (Dordrecht, Netherlands) vol. 34,1 (2012): 247-67. doi:10.1007/s11357-011-9217-5. https://pubmed.ncbi.nlm.nih.gov/21347607/

Bouilly-Gauthier D, Jeannes C, Maubert Y, et al. Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet-induced skin damage. Br J Dermatol. 2010;163(3):536-543. https://pubmed.ncbi.nlm.nih.gov/20545689/

Boulangé CL, Neves AL, Chilloux J, Nicholson JK, Dumas ME. Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med. 2016;8(1):42. Published 2016 Apr 20 https://pubmed.ncbi.nlm.nih.gov/27098727/

Buford TW. (Dis) Trust your gut: The gut microbiome in age-related inflammation, health, and disease. Microbiome. 2017;5(80):1–11. 

Clark AK, Haas KN, Sivamani RK. Edible Plants and Their Influence on the Gut Microbiome and Acne. Int J Mol Sci. 2017 May 17;18(5):1070. https://pubmed.ncbi.nlm.nih.gov/28513546/

Collins S, Reid G. Distant Site Effects of Ingested Prebiotics. Nutrients. 2016;8(9):523. Published 2016 Aug 26. https://pubmed.ncbi.nlm.nih.gov/27571098/

Codoñer FM, Ramírez-Bosca A, Climent E, et al. Gut microbial composition in patients with psoriasis. Sci Rep. 2018;8(1):3812. Published 2018 Feb 28. https://pubmed.ncbi.nlm.nih.gov/29491401/

Ellis SR, Nguyen M, Vaughn AR, Notay M, Burney WA, Sandhu S, Sivamani RK. The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions. Microorganisms. 2019 Nov 11;7(11):550. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920876/

Friedrich AD, Paz ML, Leoni J, González Maglio DH. Message in a Bottle: Dialog between Intestine and Skin Modulated by Probiotics. Int J Mol Sci. 2017 Jun 9;18(6):1067. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485927/

Greenhalgh K, Meyer KM, Aagaard KM, Wilmes P. The human gut microbiome in health: establishment and resilience of microbiota over a lifetime. Environ Microbiol. 2016 Jul;18(7):2103-16. doi: 10.1111/1462-2920.13318. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387106/

Han B, Sivaramakrishnan P, Lin CCJ, Neve IAA, He J, Tay LWR, Sowa JN, Sizovs A, Du G, Wang J, Herman C, Wang MC. Microbial genetic composition tunes host longevity. Cell. 2017;169(13):1249–62. 

Keller JM, Surawicz CM. Clostridium difficile infection in the elderly. Clin Geriatr Med. 2014;30(1):79–93. 

Litvak, Yael et al. “Colonocyte metabolism shapes the gut microbiota.” Science (New York, N.Y.) vol. 362,6418 (2018): eaat9076. doi:10.1126/science.aat9076. https://pubmed.ncbi.nlm.nih.gov/30498100/

Mariat, D et al. “The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age.” BMC microbiology vol. 9 123. 9 Jun. 2009, doi:10.1186/1471-2180-9-123. https://pubmed.ncbi.nlm.nih.gov/19508720/

Mills S, Stanton C, Lane JA, Smith GJ, Ross RP. Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients. 2019 Apr 24;11(4):923. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520976/

Nagpal R, Mainali R, Ahmadi S, Wang S, Singh R, Kavanagh K, Kitzman DW, Kushugulova A, Marotta F, Yadav H. Gut microbiome and aging: Physiological and mechanistic insights. Nutr Healthy Aging. 2018 Jun 15;4(4):267-285. https://pubmed.ncbi.nlm.nih.gov/29951588/

Peguet-Navarro J, Dezutter-Dambuyant C, Buetler T, et al. Supplementation with oral probiotic bacteria protects human cutaneous immune homeostasis after UV exposure-double blind, randomized, placebo controlled clinical trial. Eur J Dermatol. 2008;18(5):504-511. https://pubmed.ncbi.nlm.nih.gov/18693151/

Reid, Kristin M et al. “Salmonid alphavirus infection causes skin dysbiosis in Atlantic salmon (Salmo salar L.) post-smolts.” PloS one vol. 12,3 e0172856. 6 Mar. 2017, doi:10.1371/journal.pone.0172856. https://pubmed.ncbi.nlm.nih.gov/28264056/

Roudsari MR, Karimi R, Sohrabvandi S, Mortazavian AM. Health effects of probiotics on the skin. Crit Rev Food Sci Nutr. 2015;55(9):1219-40. https://pubmed.ncbi.nlm.nih.gov/24364369/

Salem I, Ramser A, Isham N, Ghannoum MA. The Gut Microbiome as a Major Regulator of the Gut-Skin Axis. Front Microbiol. 2018 Jul 10;9:1459. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048199/

Szántó M, Dózsa A, Antal D, Szabó K, Kemény L, Bai P. Targeting the gut-skin axis-Probiotics as new tools for skin disorder management. Exp Dermatol. 2019;28(11):1210-1218. https://pubmed.ncbi.nlm.nih.gov/31386766/

Zákostelská Z, Málková J, Klimešová K, et al. Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response. PLoS One. 2016;11(7):e0159539. Published 2016 Jul 19. https://pubmed.ncbi.nlm.nih.gov/27434104/

Zapata HJ, Quagliarello VJ. The microbiota and microbiome in aging: Potential implications in health and age-related diseases. J Am Geriatr Soc. 2015;63(4):776–81. https://pubmed.ncbi.nlm.nih.gov/25851728/


1.    https://pubmed.ncbi.nlm.nih.gov/29865237/

2.    https://pubmed.ncbi.nlm.nih.gov/21347607/ 

3.    https://pubmed.ncbi.nlm.nih.gov/20545689/

4.    https://pubmed.ncbi.nlm.nih.gov/27098727/

5.    https://pubmed.ncbi.nlm.nih.gov/28709450/ 

6.    https://pubmed.ncbi.nlm.nih.gov/30692128/ 

7.    https://pubmed.ncbi.nlm.nih.gov/28513546/

8.    https://pubmed.ncbi.nlm.nih.gov/27571098/

9.    https://pubmed.ncbi.nlm.nih.gov/29491401/

10.  https://pubmed.ncbi.nlm.nih.gov/31717915/ 

11.  https://pubmed.ncbi.nlm.nih.gov/28598354/ 

12.  https://pubmed.ncbi.nlm.nih.gov/27059297/ 

13.  https://pubmed.ncbi.nlm.nih.gov/28622510/ 

14.  https://pubmed.ncbi.nlm.nih.gov/24267604/ 

15.  https://pubmed.ncbi.nlm.nih.gov/30498100/ 

16.  https://pubmed.ncbi.nlm.nih.gov/19508720/ 

17.  https://pubmed.ncbi.nlm.nih.gov/31022973/ 

18.  https://pubmed.ncbi.nlm.nih.gov/29951588/

19.  https://pubmed.ncbi.nlm.nih.gov/18693151/

20.  https://pubmed.ncbi.nlm.nih.gov/28264056/

21.  https://pubmed.ncbi.nlm.nih.gov/24364369/ 

22.  https://pubmed.ncbi.nlm.nih.gov/30042740/ 

23.  https://pubmed.ncbi.nlm.nih.gov/31386766/

24.  https://pubmed.ncbi.nlm.nih.gov/27434104/

25.  https://pubmed.ncbi.nlm.nih.gov/25851728/

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